Inhibitors of branched-chain-aminotransferase-1 (BCAT1) for the treatment of brain tumors

US9114132B2 · kind B2 · utility

Assignee

• Deutsches Krebsforschungszentrum · DE

Inventors

• Bernhard Radlwimmer · Heidelberg, DE
• Martje Toenjes · Heidelberg, DE
• Sebastian Barbus · Heidelberg, DE
• Peter Lichter · Heidelberg, DE

Key dates

• Filing date: Jan 27, 2012
• Grant date: Aug 25, 2015
• Expiry date: Jan 27, 2032

Classification

• Technology area (CPC —): General

Abstract

Described is a compound capable of reducing or inhibiting (a) the biological activity of branched-chain-aminotranferase-1 (BCAT1) or (b) the expression of the gene encoding BCAT1 for use in a method of treating a neoplasia. A preferred compound is 1-(aminomethyl) cyclohexaneacetic acid (gabapentin).