Transdermal therapeutic system reinforced by ultrasounds

US9114240B2 · kind B2 · utility

Assignee

• Michael Horstmann · DE

Inventors

• Michael Horstmann · Neuwied, DE
• Andreas Koch · Heiligenhaus, DE

Key dates

• Filing date: May 11, 2007
• Grant date: Aug 25, 2015
• Expiry date: Dec 2, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N7/00
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The invention relates to a transdermal therapeutic system (10) comprising a pharmaceutical active agent formulation (13), an adhesive layer (11) comprising a contact surface (12), and at least one ultrasound transmitter (21), the side of the ultrasound transmitter opposing the contact surface being directly or indirectly adjacent to the pharmaceutical active agent formulation. The transdermal therapeutic system is a multi-layered laminate, one of the laminate layers comprising the ultrasound transmitter, another comprising the adhesive layer, and another comprising the pharmaceutical active agent formulation. Furthermore, from a top view, at least in a plane position of the transdermal therapeutic system, all of the laminate layers (11, 21, 14) are at least approximately mutually congruent and are at least approximately the size of the contact surface. The inventive system provides an ultrasound-reinforced transdermal therapeutic system characterized by an extensive use of active agents, enabling an improved absorption of active agents through the skin.