1,3,5-triazine-2-amine derivatives, preparation thereof and diagnostic and therapeutic use thereof

US9115121B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Joelle Arnaud · Montpellier, FR
• Martine Artiaga · Paris, FR
• Francis Barth · Juvignac, FR
• Laurent Hortala · Paris, FR
• Serge Martinez · Montpellier, FR
• Pascale Roux · Paris, FR

Key dates

• Filing date: Dec 11, 2012
• Grant date: Aug 25, 2015
• Expiry date: Dec 11, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds corresponding to formula (I) in which: —R1 represents a substituted phenyl; —R2 represents: —a substituted phenyl; —a heteroaromatic group, the said group being unsubstituted or substituted one or more times; —R3 represents a group Alk; —R4 represents a hydrogen atom or a (C1-C4)alkyl; —R5 represents a hydrogen atom, a (C3-C6)cycloalkyl or a (C1-C4)alkyl-O-Alk; —or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; —R6 represents a group —COOAlk, a group —CONH2 or a group —NHSO2Alk; —Alk represents a (C1-C4)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use.