Spirocyclic derivatives as histone deacetylase inhibitors

US9115148B2 · kind B2 · utility

Assignee

• DAC S.R.L. · IT

Inventors

• Mario Varasi · Milano, IT
• Florian Thaler · Rescaldina, IT
• Agnese Abate · Cologno Monzese, IT
• Giacomo Carenzi · Busto Arsizio, IT
• Ciro Mercurio · Legnano, IT
• Saverio Minucci · Pieve Emanuele, IT

Key dates

• Filing date: Nov 22, 2013
• Grant date: Aug 25, 2015
• Expiry date: Nov 22, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is related to new histone deacetylase inhibitors according to the general formula (I) wherein: the dotted line is an optional additional bond; n is zero or an integer from 1 to 4; R1 is hydrogen; C1-C6 alkyl, optionally substituted by cycloalkyl, aryl or by heteroaryl; (CO)R3; (SO2)R4; cycloalkyl; aryl; or heteroaryl; R2 is C1-C6 alkyl, optionally substituted by aryl or by heteroaryl; aryl; heteroaryl; or (CO)R5; X is CH2, oxygen or NR6; Y is a bond, CHR7 or NR8; Z is oxygen, CR9R10 or C═R11; and R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as further defined in the specification; and pharmaceutical acceptable salts thereof.