Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase
US9119845B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Nov 8, 2010 |
| Grant date | Sep 1, 2015 |
| Priority date | — |
| Expiry date | Jul 3, 2034 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A90/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a method of increasing the stability of wild-type β-glucocerebrosidase. Also provided are methods of treating and/or preventing an individual having a neurological disease in which increased expression or activity of β-glucocerebrosidase in the central nervous system would be beneficial. This method includes administering an effective amount of a pharmacologic chaperone for β-glucocerebrosidase, with the proviso that the individual does not have a mutation in the gene encoding β-glucocerebrosidase. Further provided are β-glucocerebrosidase inhibitors which have been identified as specific pharmacologic chaperones and which have been shown to increase activity of β-glucocerebrosidase in vivo in the central nervous system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.