Process for the preparation of pleuromutilins

US9120727B2 · kind B2 · utility

Assignee

• NABRIVA THERAPEUTICS GMBH · AT

Inventors

• Rosemarie Riedl · Wien, AT
• Werner Heilmayer · Staprijk, AT
• Lee Spence · Wien, AT

Key dates

• Filing date: May 23, 2011
• Grant date: Sep 1, 2015
• Expiry date: May 23, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Process for the preparation of a compound of formula Iin the form of a single stereoisomer in crystalline form, comprising deprotecting the amine group in a compound of formula IIaor in a mixture of a compound of formula IIa with a compound of formula IIband isolating a compound of formula I from the reaction mixture; compounds and salts of compounds of formula I in crystalline form; pharmaceutical compositions comprising such salts; processes for the preparation of intermediates and intermediates in a process for the preparation of a compound of formula I.