Patent · US Active

Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals

US9120783B2 · kind B2 · utility

1Cited by

3References

12Claims

0Family size

Assignee

Sanofi · FR

Inventors

Sven Ruf · Mainz, DE
Thorsten Sadowski · Frankfurt am Main, DE
Klaus Wirth · Frankfurt am Main, DE
Herman Schreuder · Frankfurt am Main, DE
Christian Buning · Frankfurt am Main, DE

Key dates

Filing date	Mar 10, 2014
Grant date	Sep 1, 2015
Priority date	—
Expiry date	Mar 10, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D487/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to compounds of the formula I,wherein A, D, E, L, G, R10, R30, R40, R50 and R60 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. They are inhibitors of the protease cathepsin A, and are useful for the treatment of diseases such as atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.