Process for the preparation of oxymorphone alkaloid and oxymorphone salts
US9120800B2 · kind B2 · utility
1Cited by
41References
20Claims
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Key dates
| Filing date | Feb 5, 2014 |
| Grant date | Sep 1, 2015 |
| Priority date | — |
| Expiry date | Feb 5, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40° C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6α-oxymorphol produced is ≦3.00 area % as determined by HPLC.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.