DNA sequence and preparation of grass pollen allergen Phl p 4 by recombinant methods

US9120866B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Helmut Fiebig · Schwarzenbek, DE
• Andreas Nandy · Hamburg, DE
• Roland Suck · Hamburg, DE
• Oliver Cromwell · Bad Nenndorf, DE
• Arnd Petersen · Bad Segeberg, DE
• Wolf-Meinhard Becker · Darmstadt, DE

Key dates

• Filing date: Feb 24, 2011
• Grant date: Sep 1, 2015
• Expiry date: Sep 9, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention also covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilized for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for the in vitro and in vivo diagnosis of pollen allergies.