Mouse having human leukemic stem cell and leukemic non-stem cell amplified therein, and method for production thereof
US9125384B2 · kind B2 · utility
0Cited by
2References
20Claims
0Family size
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Key dates
| Filing date | Oct 17, 2008 |
| Grant date | Sep 8, 2015 |
| Priority date | — |
| Expiry date | Mar 17, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0331
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to a method of selectively expanding human leukemic cells in a non-adult NOD/SCID/IL2rgnull mouse by transplanting a substance containing a leukemic stem cell derived from a human acute myelogenous leukemia patient to the mouse. In addition, the invention relates to screening for a medicament capable of eradicating leukemic stem cell (LSC), consideration of treatment methods suitable for individual patients, identification of a differentially expressed gene and the like, using a mouse with expanded human leukemic cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.