Patent · US Active

Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions

US9125951B2 · kind B2 · utility

2Cited by

30References

27Claims

0Family size

Assignee

Wyeth, LLC · US

Inventors

Stephen John Freese · Cornwall-on-Hudson, US
Annaliesa Sybil Anderson · Upper Saddle River, US
Viliam Pavliak · Pittsford, US
Kathrin Ute Jansen · Doylestown, US
Ingrid Lea Scully · Patterson, US
Tracy Dee Scott · Foristell, US
Jasdeep Singh Nanra · Suffern, US
A. Krishna Prasad · Chapel Hill, US
Bruce A. Green · Pittsford, US

Key dates

Filing date	Jun 22, 2010
Grant date	Sep 8, 2015
Priority date	—
Expiry date	Jun 22, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/64
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use. Methods for making the immunogenic conjugates of the invention involve covalent conjugation of the capsular polysaccharides with the carrier proteins using conjugation chemistry involving either 1,1-carboyl-di-1,2,4-triazole (CDT) or 3-(2-pyridyldithio)-propionyl hydrazide (PDPH).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.