99mTc imaging agents and methods of use

US9125955B2 · kind B2 · utility

Assignee

• General Electric Company · US

Inventors

• Bruce Fletcher Johnson · Scotia, US
• Randall Lee Carter · Clifton Park, US
• Michael James Rishel · Saratoga Springs, US
• Mark Christopher Patrick Darey · Charleston, US
• Tao Wu · Carlsbad, US
• Yang Yang · Parsippany, US
• John Fitzmaurice Valliant · Hamilton, CA
• Karin Ann Stephenson · Burlington, CA

Key dates

• Filing date: Nov 6, 2013
• Grant date: Sep 8, 2015
• Expiry date: Nov 6, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C311/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An embodiment of the invention comprises method of imaging a target site comprising administrating ligand of Formula I complexed to 99mTcwherein R1 and R2 are independently an alkyl or cycloalkyl; R3 is and alkyl; X is CO or SO2; Y is (CH2)n, C6H4, (OCH2CH2)n(NHCH2CH2)n and (OCH2CH2CH2)n, or a combination thereof; Z is linker group capable of conjugating to a vector; and n is an integer between 0 and 10.