Method and apparatus for adaptive control of neurostimulation using cardiac restitution

US9126045B2 · kind B2 · utility

Assignee

• Cardiac Pacemakers, Inc. · US

Inventors

• Shibaji Shome · Arden Hills, US
• Stephen B. Ruble · Lino Lakes, US
• Jason J. Hamann · Blaine, US
• Stephen J. Hahn · Shoreview, US
• Arjun D. Sharma · Windom, US

Key dates

• Filing date: Aug 15, 2012
• Grant date: Sep 8, 2015
• Expiry date: Aug 15, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/36139
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A neurostimulation system measures a cardiac parameter at various cardiac intervals and analyzes its restitution, including computing a restitution slope being a rate of change of the restitution parameter with respect to change in the cardiac interval. In various embodiments, the system uses the restitution slope to provide for adaptive control of neurostimulation. In various embodiments, one or more cardiac parameters such as action potential duration (APD), conduction velocity (CV), QT interval (QT), and/or T-wave morphology (TM) parameter are measured and analyzed for restitution of each parameter, which is then used to control the delivery of the neurostimulation.