Process for the preparation of statins in the presence of base
US9126975B2 · kind B2 · utility
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1References
6Claims
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Assignee
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Key dates
| Filing date | Jan 13, 2012 |
| Grant date | Sep 8, 2015 |
| Priority date | — |
| Expiry date | Feb 5, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D419/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the preparation of statins by means of a Julia-Kocienski reaction between an aldehyde and a sulfone derivative in the presence of an alkaline metal alkoxy base. The resulting derivatives are suitable as building blocks for statin type compounds such as cerivastatin, fluvastatin, pitavastatin and rosuvastatin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.