Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines, their use as medicament, and pharmaceutical preparations comprising them

US9127001B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Laurent Bialy · Frankfurt am Main, DE
• Katrin Lorenz · Frankfurt am Main, DE
• Klaus Wirth · Frankfurt am Main, DE
• Klaus Steinmeyer · Frankfurt am Main, DE
• Gerhard Hessler · Hofheim, DE
• Josef Pernerstorfer · Wuppertal, DE
• Joachim Brendel · Bad Vilbel, DE

Key dates

• Filing date: Sep 16, 2011
• Grant date: Sep 8, 2015
• Expiry date: Sep 16, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridines of formula (I), their use as medicament, and pharmaceutical preparations comprising them. The compounds of formula (I) act on the TASK-1 potassium channel. The compounds are particularly suitable for the treatment or prevention of atrial arrhythmias, for example atrial fibrillation (AF) or atrial flutter.