Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
US9127014B2 · kind B2 · utility
4Cited by
72References
61Claims
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Key dates
| Filing date | Dec 11, 2012 |
| Grant date | Sep 8, 2015 |
| Priority date | — |
| Expiry date | Dec 11, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.