Small molecule inhibitors of Dusp6 and uses therefor

US9127016B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Billy W. Day · Pittsburgh, US
• Waikok Michael Tsang · Pittsburgh, US
• Vasiliy N. Korotchenko · Rockville, US

Key dates

• Filing date: Mar 19, 2010
• Grant date: Sep 8, 2015
• Expiry date: Oct 17, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.