Method of inhibiting bacterial growth and biofilm formation with natural quorum sensing peptides
US9127045B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 17, 2006 |
| Grant date | Sep 8, 2015 |
| Priority date | — |
| Expiry date | Jun 19, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N1/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for selectively manipulating a growth rate of a selected bacterium comprising the step of contacting the selected bacterium with a predetermined amount of a quorum sensing molecule to affect a change in the growth rate of the selected bacterium, wherein the quorum sensing molecule is species specific, and the change in the growth rate is dependent on the amount of quorum sensing molecule in a dose-dependent fashion. Also provided are methods for treating or protecting against bacterial infections by utilizing the dose-dependent response of bacterial quorum sensing systems. The methods can be applied to a wide range of bacteria species including Streptococci, Staphylococci, and Bacilli. Compositions, medicaments and oral formulations for use with the methods are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.