Method for preparing metabolites of atorvastatin using bacterial cytochrome P450 and composition therefor
US9127249B2 · kind B2 · utility
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Key dates
| Filing date | Sep 27, 2012 |
| Grant date | Sep 8, 2015 |
| Priority date | — |
| Expiry date | Sep 27, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y114/14001
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided is a novel method for preparing metabolites of atorvastatin using bacterial cytochrome P450, and a composition therefor, and more particularly, a composition for preparing 2-hydroxylated product of 4-hydroxylated product from atorvastatin including bacterial cytochrome P 450 BM3 (CYP102A1), CYP102A1 mutants, and chimeras derived from the CYP102A1 mutants, a kit therefor, and a method for preparing thereof.
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