Patent · US Active

Cell culture medium for ADAMTS protein expression

US9127265B2 · kind B2 · utility

14Cited by

3References

29Claims

0Family size

Assignee

Baxalta Incorporated · CH

Inventors

Leopold Grillberger · Wien, AT
Alexandra Spenger · Wien, AT
Meinhard Hasslacher · Wien, AT
Rana Grillberger · Wien, AT
Manfred Reiter · Wien, AT

Key dates

Filing date	May 13, 2014
Grant date	Sep 8, 2015
Priority date	—
Expiry date	May 13, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2510/02
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides culture mediums that are useful for the expression of ADAMTS proteins, such as ADAMTS13. Methods for the expression and purification of ADAMTS proteins are also provided. In some embodiments, the mediums and methods of the invention are useful for the expression of ADAMTS proteins having high specific activities. Also provided are ADAMTS, e.g., ADAMTS13, protein compositions with high specific activities, which are expressed and purified according to the methods provided herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.