Patent · US Active

UNC-45A splice variants based cancer diagnostics and therapeutics

US9127273B2 · kind B2 · utility

0Cited by

1References

10Claims

0Family size

Assignee

The Board of Regents of the University of Texas System · US

Inventors

Henry Fredric Epstein · Bellaire, US
Wei Guo · Beijing, CN
Daisi Chen · Galveston, US
Ram Singh · Los Angeles, US

Key dates

Filing date	Jan 12, 2010
Grant date	Sep 8, 2015
Priority date	—
Expiry date	Nov 10, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/531
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Methods and compositions to diagnose and treat cancers using UNC-45A splice variants are disclosed. Expression of a human UNC-45A929 splice variant that is shorter than UNC-45A944 splice variant is increased in cancer cells including metastatic cancers. siRNA to inhibit or downregulate UNC-45A splice variants in cancers are disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.