Analysis of nucleic acids

US9127312B2 · kind B2 · utility

Assignee

• Bio-Rad Laboratories, Inc. · US

Inventors

• John Frederick Regan · San Mateo, US
• Serge Saxonov · Oakland, US
• Mike Lucero · South San Francisco, US
• Ben Hindson · Livermore, US
• Phil Belgrader · Severna Park, US
• Simant Dube · Mountain View, US
• Austin So · Pleasanton, US
• Jeffrey Mellen · San Francisco, US
• Nicholas Heredia · Störitzseestraße, US
• Kevin Ness · Pleasanton, US
• Bill W. Colston · San Ramon, US

Key dates

• Filing date: Feb 9, 2012
• Grant date: Sep 8, 2015
• Expiry date: Jun 5, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/172
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.