Method and system for advanced measurements computation and therapy planning from medical data and images using a multi-physics fluid-solid heart model

US9129053B2 · kind B2 · utility

Assignee

• Siemens Aktiengesellschaft · DE

Inventors

• Tommaso Mansi · Plainsboro, US
• Viorel Mihalef · New Brunswick, US
• Xudong Zheng · Plainsboro, US
• Bogdan Georgescu · Plainsboro, US
• Saikiran Rapaka · Ewing, US
• Puneet Sharma · Rahway, US
• Ali Kamen · Skillman, US
• Dorin Comaniciu · Princeton Junction, US

Key dates

• Filing date: Feb 1, 2013
• Grant date: Sep 8, 2015
• Expiry date: Mar 30, 2034

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2210/41
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Method and system for computation of advanced heart measurements from medical images and data; and therapy planning using a patient-specific multi-physics fluid-solid heart model is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image patient data. A patient-specific computational heart model is generated based on the patient-specific anatomical model of the left and right ventricles and patient-specific clinical data. The computational model includes biomechanics, electrophysiology and hemodynamics. To generate the patient-specific computational heart model, initial patient-specific parameters of an electrophysiology model, initial patient-specific parameters of a biomechanics model, and initial patient-specific computational fluid dynamics (CFD) boundary conditions are marginally estimated. A coupled fluid-structure interaction (FSI) simulation is performed using the initial patient-specific parameters, and the initial patient-specific parameters are refined based on the coupled FSI simulation. The estimated model parameters then constitute new advanced measurements that can be used for decision making.