Antibacterial quinoline derivatives

US9133167B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Jérôme Emile Georges Guillemont · Andé, FR
• Magali Madeleine Simone Motte · Louviers, FR
• David Francis Alain Lançois · Louviers, FR
• Wendy Mia Albert Balemans · Kalmthout, BE

Key dates

• Filing date: Apr 26, 2013
• Grant date: Sep 15, 2015
• Expiry date: Apr 26, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib):including any stereochemically isomeric form thereof,a pharmaceutically acceptable salt thereof, a N-oxide form thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.