Isolation, purification and synthesis of procyanidin B2 and uses thereof
US9133176B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 12, 2008 |
| Grant date | Sep 15, 2015 |
| Priority date | — |
| Expiry date | Mar 7, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D323/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for the synthesis, isolation, and purification of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin B2 in high yields. The isolation methods extract procyanidin B2 from a sample of bark powder from plant matter of the genus Uncaria. The isolated and/or synthesized procyanidin B2 is used to treat amyloid disease, such as Alzheimer's disease and Parkinson's disease as well as improve cognitive performance and increase learning and memory in Alzheimer's patients. Pharmaceutical compositions containing the synthesized and/or isolated procyanidin B2 are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.