Cyclic tripeptide mimetics as plasmin inhibitors

US9133194B2 · kind B2 · utility

Inventors

• Torsten Steinmetzer · Jena, DE
• Sebastian Saupe · Kaltennordheim, DE

Key dates

• Filing date: Jul 9, 2012
• Grant date: Sep 15, 2015
• Expiry date: Jul 9, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to peptide mimetics comprising the residues P4-P3-P2-P1, which were cyclized between the side chains of P3 and P2 amino acid and are, as inhibitors of the serine protease plasmin, suitable to be used to inhibit fibrinolysis and thus to reduce blood loss in hyperfibrinolytic conditions, for example during surgery.