5-membered heterocyclic amides and related compounds

US9133204B2 · kind B2 · utility

Assignee

• H. LUNDBECK A/S · DK

Inventors

• Hongbin Li · Newtown, US
• Jun Yuan · Guilford, US
• Rajagopal Bakthavatchalam · Branford, US
• Kevin Hodgetts · Killingworth, US
• Qin Guo · Branford, US
• Scott Capitosti · Middletown, US
• Jianmin Mao · Winchester, US
• David Juergen Wustrow · Ann Arbor, US

Key dates

• Filing date: Sep 9, 2014
• Grant date: Sep 15, 2015
• Expiry date: Sep 9, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

5-Membered heterocyclic amides and related compounds are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.