Method for modulating a bacterial invasion switch

US9133451B2 · kind B2 · utility

Assignee

• RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK · US

Inventors

• Haiping Cheng · New York, US
• Shari Walcott · New York, US
• Haiyang Lu · Jinan, CN
• Li-Di Luo · Hsinchu, TW
• Meghua Yang · New York, US
• Zahra Salehi · New York, US

Key dates

• Filing date: May 28, 2013
• Grant date: Sep 15, 2015
• Expiry date: May 28, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/52
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The subject matter disclosed herein pertains to the modulation of a bacterial invasion switch and the subsequent use of the bacterium to vaccinate an organism. In one embodiment, the bacterial invasion switch is modulated by changing the proteolysis of ExoR protein. In another embodiment, a mutated bacterium produces a mutant ExoR protein that resists proteolysis.