Recombinant virus products and methods for inhibition of expression of myotilin
US9133482B2 · kind B2 · utility
4Cited by
6References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 21, 2013 |
| Grant date | Sep 15, 2015 |
| Priority date | — |
| Expiry date | Oct 21, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to RNA interference-based methods for inhibiting the expression of the myotilin gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of myotilin. The methods have application in the treatment of muscular dystrophies such as Limb Girdle Muscular Dystrophy Type 1A.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.