Methods and compositions for modulating P300/CBP activity

US9138439B2 · kind B2 · utility

Assignees

• The Wistar Institute · US
• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Ronen Marmorstein · Swarthmore, US
• Xin Liu · Wuxi, CN
• Philip A. Cole · Stow, US
• Ling Wang · Seattle, US
• Erin M. Bowers · Baltimore, US
• David J. Meyers · Brookline, US
• Chandrani Mukherjee · Baltimore, US

Key dates

• Filing date: May 30, 2013
• Grant date: Sep 22, 2015
• Expiry date: May 30, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A90/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.