Patent · US Active

Modified pathogens for use as vaccines

US9138468B2 · kind B2 · utility

0Cited by
14References
14Claims
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Assignee

Inventors

Key dates

Filing dateJun 17, 2014
Grant dateSep 22, 2015
Priority date—
Expiry dateJun 17, 2034

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY02A50/30
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Described herein are microorganisms that are modified so that they have an increased ability to be recognized by the innate immune system of a eukaryote, relative to an unmodified microorganism. A microorganism may be a gram-negative bacterium that has been modified to produce high potency lipopolysaccharide, e.g., Yersinia pestis expressing LpxL. Such modified microorganisms may be used as vaccines for protection against an infection by the unmodified microorganism. They may also be used as delivery vehicles of one or more heterologous antigens, e.g., antigens from pathogens or those associated with a hyperproliferative eukaryotic cell.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.