Compositions, methods, and systems relating to controlled crystallization and/or nucleation of molecular species

US9138659B2 · kind B2 · utility

Assignee

• Massachusetts Institute of Technology · US

Inventors

• Bernhardt Levy Trout · Lexington, US
• Patrick S. Doyle · Sudbury, US
• Trevor Alan Hatton · Sudbury, US
• Allan S. Myerson · Brooklyn, US
• Ying Diao · Stanford, US
• Matthew E. Helgeson · Lompoc, US

Key dates

• Filing date: Aug 23, 2011
• Grant date: Sep 22, 2015
• Expiry date: Mar 11, 2032

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B82Y5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention generally relates to compositions, methods, and systems relating to controlled crystallization and/or nucleation of a molecular species. In some embodiments, the crystallization and/or nucleation of the molecular species may be controlled by tuning the surface chemistry and/or the morphology of a crystallization substrate. In some embodiments, the molecular species is a small organic molecule (e.g., pharmaceutically active agent).