Zwitterionic stationary phase for hydrophilic interaction liquid chromatography and preparation method thereof
US9138721B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 25, 2011 |
| Grant date | Sep 22, 2015 |
| Priority date | — |
| Expiry date | May 20, 2032 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J20/3278
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A type of liquid chromatographic stationary phase and preparation method thereof, the bonding terminal of the chromatographic stationary phase is zwitterionic functional group. The preparation method includes the following steps, alkenyl or alkynyl silane is bonded onto the surface of silica based on the horizontal polymerization approach to obtain alkenyl- or alkynyl-modified silica. Then the thiol click reaction with zwitterionic compound containing thiol group is performed to obtain the zwitterionic hydrophilic interaction chromatographic stationary phase. The present stationary phase possesses both zwitterionic characteristics and excellent hydrophilicity. It can be widely applied in the separation of variety of samples.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.