Synthesis of R-biphenylalaninol

US9139515B2 · kind B2 · utility

Assignee

• DPx Holdings B.V. · NL

Inventors

• Petrus Johannes Hermsen · Nijmegen, NL
• Peter H. Ermann · Donaustauf, DE
• Peter Riebel · Kaiseraugst, CH
• Michael Wolberg · Neutraubling, DE
• Andreas Hendrikus Maria De Vries · Echt, NL

Key dates

• Filing date: Aug 16, 2012
• Grant date: Sep 22, 2015
• Expiry date: Aug 16, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C271/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to a novel process for the synthesis of R-biphenylalaninol and to intermediate compounds that are formed in the process according to the invention, i.e. novel intermediates useful in the synthesis of R-biphenylalaninol. The invention also relates to R-biphenylalaninol, The process according to the invention, the intermediates to of R-biphenylalaninol and of R-biphenylalaninol are all useful in the synthesis of pharmaceutically active compounds.