Carboxamide compounds and their use as calpain inhibitors

US9139557B2 · kind B2 · utility

Assignee

• Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

• Andreas Kling · Mannheim, DE
• Wilfried Hornberger · Wiesbaden, DE
• Helmut Mack · Ludwigshafen, DE
• Achim Moeller · Grünstadt, DE
• Volker Nimmrich · Heidelberg, DE
• Dietmar Seemann · Schallstadt, DE
• Wilfried Lubisch · Mannheim, DE

Key dates

• Filing date: Mar 25, 2013
• Grant date: Sep 22, 2015
• Expiry date: Mar 25, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.The carboxamide compounds are compounds of the general formula Iin which R1, R2, R3a, R3b, W, Y and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula I-A.a′ and I-A.a″in which m, E, R1, R3a, R3b, R2, Ry, Rw and Rw6*have the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof.