TAM receptors and TAM receptor ligands in detection and modulation of neuropathological disease
US9139879B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 19, 2011 |
| Grant date | Sep 22, 2015 |
| Priority date | — |
| Expiry date | Aug 19, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/56
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods, compositions and kits based on TAM receptors, or TAM receptor ligands or agonists are for detection of neuropathological diseases or determination of their progression. The neural diseases include multiple sclerosis or other inflammatory neural disorders that are characterized by demyelination, oligodendrocyte cytotoxicity and microglial activation. These methods include screening cells of a subject where identification of an elevation of expression of a TAM receptor or a change in expression of a TAM receptor ligand indicates the presence of the disease presence or progression. In addition, subjects with such neuropathological diseases can be treated by administering TAM receptor ligands (such as GAS 6 or Protein S) or by administering agonists such as antibodies specific for the TAM receptors; Axl, Mer or Tyro3.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.