Systems and methods for detection of cellular stress
US9140650B2 · kind B2 · utility
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25Claims
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Key dates
| Filing date | Jul 21, 2011 |
| Grant date | Sep 22, 2015 |
| Priority date | — |
| Expiry date | Jan 8, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/6439
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
There are provided methods for detection and measurement of stress in a cell, the method including introducing a labeled tRNA into the cell and detecting a change in subcellular localization of the labeled tRNA in the cell, based on the signal emitted from the labeled tRNA. There are further provided methods and systems for the generation of a stress index of a living cell. There are further provided methods and systems for detection of stress in a living cell, comprising detection of changes in subcellular localization of labeled tRNA in a cell, wherein the detection is performed in real time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.