Tissue specific expression of antibodies in chickens
US9144229B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Mar 25, 2014 |
| Grant date | Sep 29, 2015 |
| Priority date | — |
| Expiry date | Mar 25, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/77
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Transgenes encoding exogenous antibodies are stably integrated into donor cells and are present in the somatic tissue of chimeric birds. The transgenes encode exogenous antibodies and are preferably expressed in the oviduct for collection in the egg. Tissue specificity is provided by selecting the content of the transgene accordingly. Birds whose genome is comprised of transgene-derived exogenous antibody-encoding DNA express exogenous antibodies having desirable chemical properties with increased therapeutic utility compared to antibodies derived from bacterial expression systems.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.