Compounds useful for treating AIDS

US9145367B2 · kind B2 · utility

Assignees

• ABIVAX · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• INSTITUT CURIE · FR
• Universite De Montpellier · FR

Inventors

• Jamal Tazi · Clapiers, FR
• Florence Mahuteau · Le Puy-en-Velay, FR
• Romain Najman · L'Haÿ-les-Roses, FR
• Didier Scherrer · Castelnau-le-Lez, FR
• Noelie Campos · Le Crès, FR
• Aude Garcel · Le Crès, FR

Key dates

• Filing date: Jun 14, 2010
• Grant date: Sep 29, 2015
• Expiry date: Jul 24, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compound Formula (I) wherein: Formula (II) means a pyridazine, a pyrimidine or a pyrazine group, R independently represent a hydrogen atom, a halogen atom or a group chosen among a CN group, a hydroxyl group, a COOR1 group, a (C1-C3)fluoroalkyl group, a (C1-C3)fluoroalkoxy group, a NO2 group, a NR1R2 group, a (C1-C4)alkoxy group, a phenoxy group and a (C1-C3)alkyl group, said alkyl being optionally mono-substituted by a hydroxyl group, n is 1, 2 or 3, n is 1 or 2, R is a hydrogen atom, a halogen atom or a group chosen among a (C1-C3)alkyl group, a hydroxyl group, a COOR1 group, a NO2 group, a NR1R2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C1-C3)fluoroalkyl group, a (C1-C4)alkoxy group and a CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C, for use as an agent for preventing, inhibiting or treating AIDS. Some of said compounds are new and also form part of the invention.