Bis-(sulfonylamino) derivatives for use in therapy

US9145380B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Johan Bylund · Therwil, CH
• Maria Ek · Malung, SE
• Ylva Gravenfors · Gately Drive, SE
• Gunnar Nordvall · Gately Drive, SE
• Alexander Minidis · Malung, SE
• Karl S.A. Vallin · Malung, SE
• Jenny Viklund · Kungshättan, SE
• Jörg Holenz · Munkfors, SE
• Stefan Von Berg · Mölndal, SE
• Daniel Sohn · Gately Drive, SE

Key dates

• Filing date: Dec 18, 2008
• Grant date: Sep 29, 2015
• Expiry date: Jan 22, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides compounds of formula (I) wherein R1, R3, L1, L2, G1, G2, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1.