GDF-8 inhibitors

US9145433B2 · kind B2 · utility

Assignee

• Rigel Pharmaceuticals, Inc. · US

Inventors

• Somasekhar Bhamidipati · Foster City, US
• Marina Gelman · San Francisco, US
• Pingyu Ding · Foster City, US
• Rajinder Singh · Belmont, US
• Jeffrey Clough · Redwood City, US
• Todd Kinsella · Redwood City, US
• Donald Payan · Hillsborough, US

Key dates

• Filing date: Oct 4, 2013
• Grant date: Sep 29, 2015
• Expiry date: Oct 4, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65038
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are GCF-8 inhibitors of the formula (I),and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R5, R6, X and Z are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for inhibiting GDF-8 in a cell and methods for treating a patient suffering from a disease or disorder, wherein the patient would therapeutically benefit from an increase in mass or strength of muscle tissue.