Voxel-resolution myocardial blood flow analysis
US9149244B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Mar 29, 2012 |
| Grant date | Oct 6, 2015 |
| Priority date | — |
| Expiry date | Mar 29, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30104
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A myocardial blood flow analysis scan includes incorporating a pharmacological kinetic model with the standard factor analysis model where each time activity curve is assumed to be a linear combination of factor curves. Pharmacological kinetics based factor analysis of dynamic structures (K-FADS) model can be applied, whereby a means for estimating factor curves in the myocardium that are physiologically meaningful is provided. Additional optional aspects include performing a discretization to transform continuous-time K-FADS model into a discretetime K-FADS model and application of an iterative Voxel-Resolution myocardial blood flow (V-MBF) algorithm. A V-MBF algorithm based on a model that accounts for the fact that the shape of TACs due to ischemic and normal tissue are different can be included.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.