Itraconazole compositions with improved bioavailability

US9149431B2 · kind B2 · utility

Assignees

• Abb Vie Deutschland Gmbh & Co. KG · DE
• Barrier Therapeutics, Inc. · US

Inventors

• Gunther Berndl · Herxheim, DE
• Matthias Degenhardt · Ludwigshafen, DE
• Markus Mägerlein · Mannheim, DE
• Gerrit Dispersyn · Princeton, US

Key dates

• Filing date: Jun 21, 2013
• Grant date: Oct 6, 2015
• Expiry date: Jun 21, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A solid dispersion product comprising itraconazole and hydroxypropyl methylcellulose, which satisfies the Formula 0.35>ΔHtr (1) (wherein ΔHtr represents the endotherm (J/g) accompanying a transition at about 240° C.). The solid dispersion product shows an improved bioavailability.