Methods and compositions of treating a Flaviviridae family viral infection

US9149463B2 · kind B2 · utility

Assignee

• THE BOARD OF TRUSTEES OF THE LELAND STANDFORD JUNIOR UNIVERSITY · US

Inventors

• Shirit Einav · Stanford, US
• Jeffrey S. Glenn · Palo Alto, US
• Wenjin Yang · Foster City, US
• Hadas Dvory-Sobol · Mountain View, US
• Ingrid Choong · Palo Alto, US
• Robert McDowell · San Francisco, US

Key dates

• Filing date: Mar 18, 2009
• Grant date: Oct 6, 2015
• Expiry date: Jun 4, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Briefly described, embodiments of this disclosure include compounds (e.g., such as Formula II, Formula II-a, and specific compounds shown in Table 1), pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of inhibiting HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like.