Patent · US Active

Sustained-release composition containing tetrahydropyrido[4,3-b]indole derivatives and preparation of the derivatives

US9149467B2 · kind B2 · utility

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1References

4Claims

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Assignee

INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES · CN

Inventors

Song Li · Beijing, CN
Wu Zhong · Beijing, CN
Zhibing Zheng · Beijing, CN
Junhai Xiao · Beijing, CN
Bing Li · Towaco, US
Yunde Xie · Beijing, CN
Xinbo Zhou · Beijing, CN

Key dates

Filing date	Mar 29, 2010
Grant date	Oct 6, 2015
Priority date	—
Expiry date	Mar 29, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a sustained-release composition containing 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole or a pharmaceutically acceptable salt thereof as an active ingredient, preparation thereof and the compound. The composition is suitable for oral administration by one time per day, and achieves the peak plasma concentration at 1.0 to 3 hours after oral administration. The composition is suitable for manufacturing a medicament for treatment of cognitive dysfunction syndrome, Alzheimer's disease, Parkinson's disease, Huntington's disease, or senile dementia.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.