Polyamine transporter selective compounds as anti cancer agents
US9150495B2 · kind B2 · utility
4Cited by
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2Claims
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Key dates
| Filing date | Jul 29, 2013 |
| Grant date | Oct 6, 2015 |
| Priority date | — |
| Expiry date | Jul 29, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polyamine dimers provide highly efficient drugs for targeting cancer cells with active polyamine transporters.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.