Patent · US Active

Dual-acting antihypertensive agents

US9150514B2 · kind B2 · utility

1Cited by

43References

26Claims

0Family size

Assignee

Theravance Biopharma R&D IP, LLC · US

Inventors

Paul Allegretti · Fort Collins, US
Seok-Ki Choi · Ann Arbor, US
Roland Gendron · San Francisco, US
Paul R. Fatheree · San Francisco, US
Keith Jendza · Boston, US
Robert Murray McKinnell · Millbrae, US
Darren McMurtrie · Daly City, US
Brooke Olson · Williamstown, US

Key dates

Filing date	Oct 23, 2014
Grant date	Oct 6, 2015
Priority date	—
Expiry date	Oct 23, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D513/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention is directed to methods for treating hypertension or heart failure using compounds having the formula:wherein: Ar, r, Y, Z, Q, W, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. In particular embodiments, the invention uses compounds having formula IIIa, IVa, Va:These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.