Patent · US Active

Pure intermediate

US9150524B2 · kind B2 · utility

0Cited by

1References

16Claims

0Family size

Assignee

Generics [UK] Limited · GB

Inventors

Vinayak Govind Gore · Panvel, IN
Vinay Kumar Shukla · Jamkhed, IN
Sandeep Mekde · Jamkhed, IN
Suresh Hasbe · Jamkhed, IN
Shreyas Bhandari · Jamkhed, IN
Dhananjay Shinde · Jamkhed, IN
Madhukar Shaligram Patil · Jamkhed, IN

Key dates

Filing date	Aug 26, 2011
Grant date	Oct 6, 2015
Priority date	—
Expiry date	Aug 26, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to an improved process for the preparation of Letrozole (I) and its synthetic intermediate 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III). In particular, it relates to a process to prepare Letrozole and its intermediate (III) substantially free from regioisomeric impurities. The present invention further relates to acid addition salts of 4-[(1-(1,2,4-triazoly)methyl]benzonitrile (III) such as the oxalate salt, and also to Letrozole (I), the intermediate (III) and salts thereof preparable by the processes of the present invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.