Carboxamide compounds and their use as calpain inhibitors

US9150553B2 · kind B2 · utility

Assignee

• Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

• Wilfried Hornberger · Wiesbaden, DE
• Helmut Mack · Ludwigshafen, DE
• Andreas Kling · Mannheim, DE
• Achim Moeller · Grünstadt, DE
• Barbara Vogg · Ludwigshafen, DE
• Jürgen Delzer · Speyer, DE
• Gisela Backfisch · Dossenheim, DE
• Armin Beyerbach · Bad Dürkheim, DE

Key dates

• Filing date: Dec 29, 2008
• Grant date: Oct 6, 2015
• Expiry date: Apr 13, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/052
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel carboxamide compounds of the formula I and their use for the manufacture of a medicament. The carboxamide compounds are prodrugs of inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.