Nicotinic receptor compounds

US9150581B2 · kind B2 · utility

Assignees

• Research Triangle Institute · US
• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US
• Virginia Commonwealth University · US

Inventors

• Frank Ivy Carroll · Durham, US
• Pauline Wanjiku Ondachi · Raleigh, US
• Hernan A. Navarro · Chapel Hill, US
• M. Imad Damaj · Richmond, US
• James H. Woods · Ann Arbor, US
• Emily M. Jutkiewicz · Dexter, US

Key dates

• Filing date: Dec 26, 2012
• Grant date: Oct 6, 2015
• Expiry date: Dec 26, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds and compositions for promoting smoking cessation or decreasing tobacco use or nicotine addiction are provided. The compounds are 2′-fluoro-3′-(substituted phenyl) deschloroepibatidine analogs. The compounds have been found to modulate neuronal nicotine acetylcholine receptors and are useful in methods for the treatment of conditions or disorders influenced by the modulation of neuronal nicotinic acetylcholine receptors.